Macrolactins O-R, glycosylated 24-membered lactones from Bacillus sp. AH159-1

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Title
Macrolactins O-R, glycosylated 24-membered lactones from Bacillus sp. AH159-1
Author(s)
C J Zheng; Sangku Lee; C H Lee; Won Gon Kim
Bibliographic Citation
Journal of Natural Products, vol. 70, no. 10, pp. 1632-1635
Publication Year
2007
Abstract
In the course of screening for inhibitors of Staphylococcus aureus peptide deformylase, four new glycosylated macrolactin compounds, macrolactins O (1), P (2), Q (3), and R (4), along with the known macrolactins B (5) and C (6), have been isolated from the liquid cultures of Bacillus sp. AH159-1. The structures of compounds 1-4 were assigned on the basis of MS and NMR data. They inhibited S. aureus peptide deformylase and also showed antibacterial activity against Escherichia coli and Staphylococcus aureus.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np0701327
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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