Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia
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- Title
- Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia
- Author(s)
- C Z Wu; X F Cai; N T Dat; S S Hong; A R Han; E K Seo; B Y Hwang; J X Nan; D Lee; Jung Joon Lee
- Bibliographic Citation
- Tetrahedron Letters, vol. 48, no. 50, pp. 8861-8864
- Publication Year
- 2007
- Abstract
- Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC50 value of 6.1 μM.
- Keyword
- FabaceaeHypoxia-inducible factor-1MeroterpenoidPsoralea corylifolia
- ISSN
- 0040-4039
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.tetlet.2007.10.059
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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