Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

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Title
Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites
Author(s)
Kyeong Lee; J S Ryu; Y Jin; Won Cheol Kim; N Kaur; Sang Jeon Chung; Y J Jeon; J T Park; J S Bang; H S Lee; T Y Kim; Jung Joon Lee; Young-Soo Hong
Bibliographic Citation
Organic & Biomolecular Chemistry, vol. 6, no. 2, pp. 340-348
Publication Year
2008
Abstract
A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.
ISSN
1477-0520
Publisher
Royal Soc Chem
DOI
http://dx.doi.org/10.1039/b713407j
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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