Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

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dc.contributor.authorKyeong Lee-
dc.contributor.authorJ S Ryu-
dc.contributor.authorY Jin-
dc.contributor.authorWon Cheol Kim-
dc.contributor.authorN Kaur-
dc.contributor.authorSang Jeon Chung-
dc.contributor.authorY J Jeon-
dc.contributor.authorJ T Park-
dc.contributor.authorJ S Bang-
dc.contributor.authorH S Lee-
dc.contributor.authorT Y Kim-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorYoung-Soo Hong-
dc.date.accessioned2017-04-19T09:08:48Z-
dc.date.available2017-04-19T09:08:48Z-
dc.date.issued2008-
dc.identifier.issn1477-0520-
dc.identifier.uri10.1039/b713407jko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8237-
dc.description.abstractA new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.-
dc.publisherRoyal Soc Chem-
dc.titleSynthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites-
dc.title.alternativeSynthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites-
dc.typeArticle-
dc.citation.titleOrganic & Biomolecular Chemistry-
dc.citation.number2-
dc.citation.endPage348-
dc.citation.startPage340-
dc.citation.volume6-
dc.contributor.affiliatedAuthorKyeong Lee-
dc.contributor.affiliatedAuthorWon Cheol Kim-
dc.contributor.affiliatedAuthorSang Jeon Chung-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.alternativeName이경-
dc.contributor.alternativeName류정-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName김원철-
dc.contributor.alternativeNameKaur-
dc.contributor.alternativeName정상전-
dc.contributor.alternativeName전영진-
dc.contributor.alternativeName박준태-
dc.contributor.alternativeName방지-
dc.contributor.alternativeName이홍-
dc.contributor.alternativeName김태-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName홍영수-
dc.identifier.bibliographicCitationOrganic & Biomolecular Chemistry, vol. 6, no. 2, pp. 340-348-
dc.identifier.doi10.1039/b713407j-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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