Hyaluronic acid induces transglutaminase II to enhance cell motility; role of Rac1 and FAK in the induction of transglutaminase II

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Title
Hyaluronic acid induces transglutaminase II to enhance cell motility; role of Rac1 and FAK in the induction of transglutaminase II
Author(s)
Y Kim; Young Woo Park; Y S Lee; D Jeong
Bibliographic Citation
Biotechnology Letters, vol. 30, no. 1, pp. 31-39
Publication Year
2008
Abstract
The role of transglutaminase II (TGase II) in hyaluronic acid (HA)-promoted melanoma cell motility was investigated. HA induced the expression of TGase II via the nuclear factor κB (NF-kB) in melanoma cells. HA increased the Rac1 activity and phosphorylation of focal adhesion kinase (FAK). Transfection by lipofectamine of dominant-negative Rac1, and FAK-related non-kinase (FRNK), an endogenous inhibitor of FAK, suppressed the induction of TGase II. This suggests that Rac1 and FAK mediate induction of TGase II by HA. HA-promoted melanoma cell motility was inhibited by cystamine, an inhibitor of TGase II, and overexpression of TGase II enhanced melanoma cell motility through reactive oxygen species. Taken together, HA promotes melanoma cell motility through activation of Rac1, FAK, and induction of TGase II.
Keyword
Focal adhesion kinaseHyaluronic acidMotilityRac1Transglutaminase II
ISSN
0141-5492
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s10529-007-9496-1
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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