Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds

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Title
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds
Author(s)
H S Kwon; Min Jung Kim; Hyung Jae Jung; M S Yang; K H Park; Tae Sook JeongWoo Song Lee
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 1, pp. 194-198
Publication Year
2008
Abstract
Six diarylbutane lignans 1-5 and one aryltetralin lignan 6 were isolated from the methanol (95%) extracts of Myristica fragrans seeds and then 7-methyl ether diarylbutane lignan 4 has proven to be new a compound. Their compounds 1-7 were evaluated for LDL-antioxidant activity to identify the most potent LDL-antioxidant 3 with an IC50 value of 2.6 μM in TBARS assay. Due to its potency, compound 3 was tested for complementary in vitro investigations, such as lag time (140 min at 1.0 μM), relative electrophoretic mobility (REM) of ox-LDL (inhibition of 80% at 20 μM and 72% at 10 μM), and fragmentation of apoB-100 (inhibition of 93% at 20 μM) on copper-mediated LDL oxidation. In macrophage-mediated LDL oxidation, the TBARS formation was also inhibited by compound 3.
Keyword
LDL-antioxidantLignanMyristica fragrans
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2007.10.098
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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