K Chun; Song Kyu Park; Hwan Mook Kim; Y Choi; M H Kim; C H Park; B Y Joe; T G Chun; H M Choi; H Y Lee; S H Hong; M S Kim; K Y Nam; G Han
Bioorganic & Medicinal Chemistry, vol. 16, no. 1, pp. 530-535
A series of coumarin types MMP inhibitors were designed based on gelastatin hydroxamates (1) and evaluated for TACE, cellular TNF-α, and NO inhibitory activities. Among them, compounds 9b had potent inhibitory activities in enzymatic and cellular assays and good selectivity to MMP-2 and MMP-9. Further investigation of 9b will be carried out for its efficacy in RA animal model system.