Farnesyl protein transferase inhibitory components of Lithospermum erythrorhizon
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- Title
- Farnesyl protein transferase inhibitory components of Lithospermum erythrorhizon
- Author(s)
- S J Kim; Byoung-Mog Kwon; S H Kim; N I Baek; J H Yang; J J Lee; S I Lee; Y E Kwon; H W Park; J H Lee; J S Park; D K Kim
- Bibliographic Citation
- Natural Products Sciences, vol. 13, no. 4, pp. 328-331
- Publication Year
- 2007
- Abstract
- The methanolic extract of the roots of Lithospermum erythrorhizon (Boraginaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three naphthoquinone compounds, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.
- ISSN
- I000-0147
- Publisher
- Korean Society of Pharmacognosy
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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