Farnesyl protein transferase inhibitory components of Lithospermum erythrorhizon

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Title
Farnesyl protein transferase inhibitory components of Lithospermum erythrorhizon
Author(s)
S J Kim; Byoung-Mog Kwon; S H Kim; N I Baek; J H Yang; J J Lee; S I Lee; Y E Kwon; H W Park; J H Lee; J S Park; D K Kim
Bibliographic Citation
Natural Products Sciences, vol. 13, no. 4, pp. 328-331
Publication Year
2007
Abstract
The methanolic extract of the roots of Lithospermum erythrorhizon (Boraginaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three naphthoquinone compounds, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.
Keyword
boraginaceaeFPTaselithospermum erythrorhizonnaphthoquinone
ISSN
I000-0147
Publisher
Korean Society of Pharmacognosy
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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