Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug

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Title
Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug
Author(s)
H Y Park; K S Oh; H M Koo; S H Cho; Sang Jeon Chung; Yong Taik Lim; D Kim; S H Yuk
Bibliographic Citation
Journal of Microencapsulation, vol. 25, no. 2, pp. 106-110
Publication Year
2008
Abstract
Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/ intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).
Keyword
HeparinMicroparticlePluronicPolyvinylalcoholSustained release of ionic drug
ISSN
0265-2048
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/02652040701800917
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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