Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe = Zingiber officinale Roscoe에서 분리한 생리활성 물질

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Title
Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe = Zingiber officinale Roscoe에서 분리한 생리활성 물질
Author(s)
J S Kim; S I Lee; H W Park; J H Yang; T Y Shin; Y C Kim; N I Baek; S H Kim; S U Choi; Byoung-Mog Kwon; K H Leem; M Y Jung; D K Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 31, no. 4, pp. 415-418
Publication Year
2008
Abstract
Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53-/-, c-myc, K-ras) and C2 (genotype: p53 -/-, c-myc, Akt), with ED50 values of 0.58 μM (C1) and 10.7 μM (C2).
Keyword
Cell proliferationCytotoxicityGingerolShogaolZingiber officinaleZingiberaceae
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-001-1172-y
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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