Hypoxia-inducible factor-1 and nuclear factor-κB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia

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Title
Hypoxia-inducible factor-1 and nuclear factor-κB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia
Author(s)
C Z Wu; S S Hong; X F Cai; N T Dat; J X Nan; B Y Hwang; Jung Joon Lee; D Lee
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 8, pp. 2619-2623
Publication Year
2008
Abstract
Two new meroterpenoids, 12,13-dihydro-12,13-dihydroxybakuchiol (2) and (12′S)-bisbakuchiol C (3), were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). The structures of 2 and 3 were elucidated by spectroscopic and chemical methods. Six meroterpenoids isolated from P. corylifolia and three semi-synthetic analogues were evaluated for HIF-1 and NF-κB inhibition, and O-methyl and O-ethylbakuchiols (6 and 7) inhibited HIF-1 and NF-κB activation without significantly decreasing the viability of the AGS and HeLa cells, respectively.
Keyword
FabaceaeHypoxia-inducible factor-1MeroterpenoidsNuclear factor-κBPsoralea corylifolia
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2008.03.028
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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