Comparative proteomic analysis of peripheral blood mononuclear cells from atopic dermatitis patients and healthy donors = 아토피환자와 정상인의 혈액의 비교단백질체학분석

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Title
Comparative proteomic analysis of peripheral blood mononuclear cells from atopic dermatitis patients and healthy donors = 아토피환자와 정상인의 혈액의 비교단백질체학분석
Author(s)
Won Kon-KimHyun Ju Cho; S I Ryu; H R Hwang; D H Kim; H Y Ryu; Jin Woong Chung; T Y Kim; Byoung Chul ParkKwang-Hee Bae; Y Ko; Sang Chul Lee
Bibliographic Citation
BMB Reports, vol. 41, no. 8, pp. 597-603
Publication Year
2008
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease that induces changes in various inflammatory skin cells. The prevalence of AD is as high as 18% in some regions of the world, and is steadily rising. However, the pathophysiology of AD is poorly understood. To identify the proteins involved in AD pathogenesis, a comparative proteomic analysis of protein expression in peripheral blood mononuclear cells isolated from AD patients and healthy donors was conducted. Significant changes were observed in the expressions of fourteen proteins, including the vinculin, PITPNB, and Filamin A proteins. Among the proteins, α-SNAP and FLNA decreased significantly, and PITPNB increased significantly in AD patients compared with control subjects; these findings were further confirmed by real-time PCR and Western blot analysis. The comparative proteome data may provide a valuable clue to further understand AD pathogenesis, and several differentially regulated proteins may be used as biomarkers for diagnosis and as target proteins for the development of novel drugs.
Keyword
Atopic dermatitisBiomarkerPeripheral blood mononuclear cellsProteomics
ISSN
1225-8687
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5483/BMBRep.2008.41.8.597
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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