Isolation of Sorangium cellulosum carrying epothilone gene clusters

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Title
Isolation of Sorangium cellulosum carrying epothilone gene clusters
Author(s)
H Hyun; J Chung; Jihoon Kim; Jong Suk Lee; Byoung-Mog Kwon; Kwang Hee Son; K Cho
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 18, no. 8, pp. 1416-1422
Publication Year
2008
Abstract
Epothilone and its analogs are a potent new class of anticancer compounds produced by myxobacteria. Thus, in an effort to identify new myxobacterial strains producing epothilone and its analogs, cellulose-degrading myxobacteria were isolated from Korean soils, and 13 strains carrying epothilone biosynthetic gene homologs were screened using a polymerase chain reaction. A migration assay revealed that Sorangium cellulosum KYC3013, 3016, 3017, and 3018 all produced microtubule-stabilizing compounds, and an LCMS/MS analysis showed that S. cellulosum KYC3013 synthesized epothilone A.
Keyword
epothilonemyxobacteriasorangium cellulosum
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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