Open Access@KRIBBDivision of A.I. & Biomedical ResearchMicrobiome Convergence Research Center1. Journal Articles
Isolation of Sorangium cellulosum carrying epothilone gene clusters
Cited 0 time in 
Metadata Downloads
- Title
- Isolation of Sorangium cellulosum carrying epothilone gene clusters
- Author(s)
- H Hyun; J Chung; Jihoon Kim; Jong Suk Lee; Byoung-Mog Kwon; Kwang Hee Son; K Cho
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 18, no. 8, pp. 1416-1422
- Publication Year
- 2008
- Abstract
- Epothilone and its analogs are a potent new class of anticancer compounds produced by myxobacteria. Thus, in an effort to identify new myxobacterial strains producing epothilone and its analogs, cellulose-degrading myxobacteria were isolated from Korean soils, and 13 strains carrying epothilone biosynthetic gene homologs were screened using a polymerase chain reaction. A migration assay revealed that Sorangium cellulosum KYC3013, 3016, 3017, and 3018 all produced microtubule-stabilizing compounds, and an LCMS/MS analysis showed that S. cellulosum KYC3013 synthesized epothilone A.
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
- Files in This Item:
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.