Synthesis and cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6,9-tri-azacyclopenta[b]anthracene-5,10-dions

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Title
Synthesis and cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6,9-tri-azacyclopenta[b]anthracene-5,10-dions
Author(s)
J H Kwak; K Namgoong; J K Jung; Jungsook Cho; Hwan Mook Kim; Song Kyu Park; Young Ah Yoo; Joo Hee Kwon; H Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 31, no. 8, pp. 995-998
Publication Year
2008
Abstract
A series of 2-alkyl-2,3-dihydro-1H-2,6,9-triazacyclopenta[b]anthracene-5, 10-diones (4a-f) were synthesized and their in vitro cytotoxic activities were evaluated against six human cancer cell lines (HCT15, SK-OV-3, A549, SNB19, MCF7 and MCF7/ADR). A number of compounds including 4c and 4d showed 2-180 times more potent cytotoxic activity than doxorubicin against all human cancer cell lines tested. Furthermore, these compounds retained considerable cytotoxic activity against the doxorubicin-resistant cell line MCF7/ADR, implying their therapeutic potential to treat doxorubicin-resistant tumors.
Keyword
Cytotoxic activityTriazacyclopenta[b]anthracene-5,10-diones
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-001-1258-6
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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