Epigallocatechin gallate stimulates glucose uptake through the phosphatidylinositol 3-kinase-mediated pathway in L6 rat skeletal muscle cells = Epigallocatechin gallate는 L6마우스 골근세포 phosphatidylinositol 3-kinase-mediated pathway통해 포도당흡수 촉진
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- Epigallocatechin gallate stimulates glucose uptake through the phosphatidylinositol 3-kinase-mediated pathway in L6 rat skeletal muscle cells = Epigallocatechin gallate는 L6마우스 골근세포 phosphatidylinositol 3-kinase-mediated pathway통해 포도당흡수 촉진
- K H Jung; H S Choi; D H Kim; M Y Han; U J Chang; S V Yim; B C Song; Chul Ho Kim; S A Kang
- Bibliographic Citation
- Journal of Medicinal Food, vol. 11, no. 3, pp. 429-434
- Publication Year
- The effect of epigallocatechin gallate (EGCG) on glucose uptake was studied in L6 rat skeletal muscle cells. Glucose uptake assay revealed that EGCG increased glucose uptake >70% compared to control. EGCG-stimulated glucose uptake was blocked by LY294002, an inhibitor of phosphatidylinositol (PI) 3-kinase, which is a major regulatory molecule in glucose uptake pathways. However, AMP-activated protein kinase (AMPK), which is another crucial mediator in independent glucose uptake pathways, did not inhibit EGCG-stimulated glucose uptake by SB203585, a specific inhibitor of the AMPK downstream mediator, p38 mitogen-activated protein kinase (MAPK). We also found that EGCG increased the phosphorylation level of protein kinase B and PI 3-kinase activity, when assessed by PI 3-kinase assay, whereas no increase in the phosphorylation level of AMPK and p38 MAPK was observed. Taken together, these results suggest that EGCG might stimulate glucose uptake, not AMPK-mediated but PI 3-kinase-mediated, in skeletal muscle cells, thereby contributing to glucose homeostasis.
- AMP-activated protein kinase; Epigallocatechin gallate; Glucose uptake; Phosphatidylinositol 3-kinase; Skeletal muscle
- Mary Ann Liebert, Inc
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- Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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