Biocompatible polymer-nanoparticles-based bimodal imaging contrast agents for the labeling and tracking of dendritic cells

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Title
Biocompatible polymer-nanoparticles-based bimodal imaging contrast agents for the labeling and tracking of dendritic cells
Author(s)
Yong Taik Lim; Young Woock Noh; Jeong Hyun Han; Q Y Cai; K H Yoon; Bong Hyun Chung
Bibliographic Citation
Small, vol. 4, no. 10, pp. 1640-1645
Publication Year
2008
Abstract
Disulfonated inldocyanine green (ICG) was chosen as the optical modality in the synthesis of bimodal imaging contrast agents for the labeling and tracking of dendritic cells (DC). ICG and iron oxide nanoparticles were encapsulated by using biocompatible polymer poly(lactide-co-glycolide) (PLGA), and ICG molecules were non-covalently bond with human serum albumin (HSA). The results show that binding of HSA proteins with ICG would enhance the compatibility of PLGA in the organic phase with ICG in the aqueous phase. The PLGA nanoparticles are found to generate MR contrast signals, and the increase in the contamination of the nanoparticles led to a decrease in the signal integrity. It is confirmed that PLGA nanoparticles containing iron oxide nanoparticles internalized into DCs, while a decrease in the signal integrity of DCs labels with PLGA nanoparticles is also observed.
Keyword
Biocompatible materialsContrast agentsFluorescenceMagnetic resonance imagingNanoparticles
ISSN
1613-6810
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/smll.200800582
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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