Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B

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Title
Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B
Author(s)
P T Thuong; Chul Ho Lee; T T Dao; P H Nguyen; W G Kim; S J Lee; W K Oh
Bibliographic Citation
Journal of Natural Products, vol. 71, no. 10, pp. 1775-1778
Publication Year
2008
Abstract
Phytochemical study on a methanol-soluble extract of the leaves of persimmon (Diospyros kaki) resulted in the isolation of two new ursane-type triterpenoids, 3α,19α-dihydroxyurs-12,20(30)-dien-24,28-dioic acid (1) and 3α,19α-dihydroxyurs-12-en-24,28-dioic acid (2), together with 12 known ursane- and oleanane-type triterpenoids (3-14). Triterpenoids with a 3β-hydroxy group were found to inhibit protein tyrosine phosphatase 1B (PTP1B) activity, with IC50 values ranging from 3.1 ± 0.2 to 18.8 ± 1.3 μM, whereas those with a 3α-hydroxy moiety were not active.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np800298w
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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