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- Title
- Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression
- Author(s)
- N T Dat; J H Lee; Kyeong Lee; Young-Soo Hong; Y H Kim; Jung Joon Lee
- Bibliographic Citation
- Journal of Natural Products, vol. 71, no. 10, pp. 1696-1700
- Publication Year
- 2008
- Abstract
- NF-κB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation. Bioassay-guided fractionation of the n-hexane-soluble fraction of a methanol extract of Amorpha fruticosa afforded four new compounds, 5, 7, 8, and 9, and eight known compounds. Their structures were elucidated by spectroscopic methods. All compounds inhibited NF-κB activity, and tephrosin (1), 11-hydroxytephrosin (2), and deguelin (3) were the most active, with IC50 values of 0.11, 0.19, and 0.22 μM, respectively, in TNF-α-stimulated HeLa cell-based reporter gene assays. Further investigations showed that compounds 1, 5, and 6 blocked NF-κB/DNA binding activity and suppressed the expression of NF-κB target genes.
- ISSN
- 0163-3864
- Publisher
- Amer Chem Soc
- DOI
- http://dx.doi.org/10.1021/np800383q
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
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