Upregulation of NF-κB upon differentiation of mouse embryonic stem cells

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Title
Upregulation of NF-κB upon differentiation of mouse embryonic stem cells
Author(s)
Y E Kim; H B Kang; J A Park; Ki Hoan Nam; H J Kwon; Y Lee
Bibliographic Citation
BMB Reports, vol. 41, no. 10, pp. 705-709
Publication Year
2008
Abstract
NF-κB is a transcriptional regulator involved in many biological processes including proliferation, survival, and differentiation. Recently, we reported that expression and activity of NF-κB is comparatively low in undifferentiated human embryonic stem (ES) cells, but increases during differentiation. Here, we found a lower expression of NF-κB p65 protein in mouse ES cells when compared with mouse embryonic fibroblast cells. Protein levels of NF-κB p65 and relB were clearly enhanced during retinoic acid-induced differentiation. Furthermore, increased DNA binding activity of NF-κB in response to TNF-α, an agonist of NF-κB signaling, was seen in differentiated but not undifferentiated mouse ES cells. Taken together with our previous data in human ES cells, it is likely that NF-κB expression and activity of the NF-κB signaling pathway is comparatively low in undifferentiated ES cells, but increases during differentiation of ES cells in general.
Keyword
differentiationembryonic stem cellsexpressionNF-κBupregulation
ISSN
1225-8687
Publisher
South Korea
DOI
http://dx.doi.org/10.5483/BMBRep.2008.41.10.705
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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