Triterpenoids and a sterol from the stem-bark of Styrax japonica and their protein tyrosine phosphatase 1B inhibitory activities
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- Triterpenoids and a sterol from the stem-bark of Styrax japonica and their protein tyrosine phosphatase 1B inhibitory activities
- J H Kwon; M J Chang; H W Seo; J H Lee; B S Min; M Na; J C Kim; M H Woo; J S Choi; Hyeong Kyu Lee; K Bae
- Bibliographic Citation
- Phytotherapy Research, vol. 22, no. 10, pp. 1303-1306
- Publication Year
- Five pentacyclic triterpenoids (1-5) and a sterol (6) were isolated from the stem-bark of Styrax japonica. The six compounds, 1-6, were determined to be 3β-acetoxy-28-hydroxyolean-12-ene (1), 3β-acetoxyolean-12-en-28-acid (2), 3β-acetoxyolean-12-en-28-aldehyde (3), 3β-acetoxy-17β- hydroxy-28-norolean-12-ene (4), taraxerol (5) and stigmasterol (6), respectively, by spectroscopic means, including the 2D-NMR technique. Compound 4 is a newly discovered natural compound. The protein tyrosine phosphatase 1B (PTP1B) inhibitory activities of the isolated compounds (1-6) were determined in vitro. Among the isolated compounds, 3β-acetoxyolean-12-en-28-acid (2) and 3β-acetoxyolean-12-en-28-aldehyde (3) had the most potent inhibitory PTP1B activity, with IC50 values of 7.8 and 9.3 μm, respectively.
- 3β-acetoxyolean- 12-en-28-acid; 3β-acetoxyolean-12-en-28-aldehyde; PTP1B inhibitory activity; styracaceae; styrax japonica
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