Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia = 파고지로부터 분리한 ACAT저해물질 bavachin과 isobavachalcone

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Title
Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia = 파고지로부터 분리한 ACAT저해물질 bavachin과 isobavachalcone
Author(s)
Jung Ho Choi; Mun Chual RhoSeung Woong Lee; Ji Na Choi; K Kim; G Y Song; Young Kook Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 31, no. 11, pp. 1419-1423
Publication Year
2008
Abstract
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays important roles in intestinal absorption of cholesterol, hepatic production of lipoproteins and accumulation of cholesteryl ester within macrophages and smooth muscle cells. Ethanol extract of Psoralea corylifolia showed a significant inhibition of ACAT enzyme. Via bioactivity-guided fractionation of the ethanol extract of Psoralea corylifolia, two prenylated flavonoids were isolated. Their structures were determined as bavachin (1) and isobavachalcone (2) by spectroscopic analysis (1H-, 13C-NMR, 2DNMR, and ESI-MS). The IC50 values were 86.0 (1) and 48.0 (2) μM in the ACAT assay system using rat liver microsome. Compound 2 also decreased cholesteryl ester formations in HepG2 cells. In addition, this compound showed a noncompetitive type of inhibition of ACAT.
Keyword
Acyl-coenzyme A: cholesterol acyltransferase (ACAT)AtherosclerosisEnzyme assayHypolipidemiaPrenylated flavonoidsPsoralea corylifolia
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-001-2126-x
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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