Flavanones from the stem bark of Erythrina abyssinica

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Title
Flavanones from the stem bark of Erythrina abyssinica
Author(s)
L Cui; P T Thuong; Hyun Sun Lee; D T Ndinteh; J T Mbafor; Z T Fomum; W K Oh
Bibliographic Citation
Bioorganic & Medicinal Chemistry, vol. 16, no. 24, pp. 10356-10362
Publication Year
2008
Abstract
Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC50 values ranging from 13.9 ± 2.1 to 19.0 ± 1.8 μM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B.
Keyword
2,2-Dimethylpyrano ringErythrina abyssinicaFlavanonePTP1B inhibitor
ISSN
0968-0896
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmc.2008.10.012
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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