Flavanones from the stem bark of Erythrina abyssinica
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | L Cui | - |
| dc.contributor.author | P T Thuong | - |
| dc.contributor.author | Hyun Sun Lee | - |
| dc.contributor.author | D T Ndinteh | - |
| dc.contributor.author | J T Mbafor | - |
| dc.contributor.author | Z T Fomum | - |
| dc.contributor.author | W K Oh | - |
| dc.date.accessioned | 2017-04-19T09:12:25Z | - |
| dc.date.available | 2017-04-19T09:12:25Z | - |
| dc.date.issued | 2008 | - |
| dc.identifier.issn | 0968-0896 | - |
| dc.identifier.uri | 10.1016/j.bmc.2008.10.012 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8743 | - |
| dc.description.abstract | Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC50 values ranging from 13.9 ± 2.1 to 19.0 ± 1.8 μM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B. | - |
| dc.publisher | Elsevier | - |
| dc.title | Flavanones from the stem bark of Erythrina abyssinica | - |
| dc.title.alternative | Flavanones from the stem bark of Erythrina abyssinica | - |
| dc.type | Article | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry | - |
| dc.citation.number | 24 | - |
| dc.citation.endPage | 10362 | - |
| dc.citation.startPage | 10356 | - |
| dc.citation.volume | 16 | - |
| dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
| dc.contributor.alternativeName | Cui | - |
| dc.contributor.alternativeName | Thuong | - |
| dc.contributor.alternativeName | 이현선 | - |
| dc.contributor.alternativeName | Ndinteh | - |
| dc.contributor.alternativeName | Mbafor | - |
| dc.contributor.alternativeName | Fomum | - |
| dc.contributor.alternativeName | 오원근 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry, vol. 16, no. 24, pp. 10356-10362 | - |
| dc.identifier.doi | 10.1016/j.bmc.2008.10.012 | - |
| dc.subject.keyword | 2,2-Dimethylpyrano ring | - |
| dc.subject.keyword | Erythrina abyssinica | - |
| dc.subject.keyword | Flavanone | - |
| dc.subject.keyword | PTP1B inhibitor | - |
| dc.subject.local | 2,2-Dimethylpyrano ring | - |
| dc.subject.local | Erythrina abyssinica | - |
| dc.subject.local | Flavanone | - |
| dc.subject.local | PTP1B inhibitor | - |
| dc.subject.local | PTP1B inhibitors | - |
| dc.description.journalClass | Y | - |
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- Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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