Flavanones from the stem bark of Erythrina abyssinica
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- Title
- Flavanones from the stem bark of Erythrina abyssinica
- Author(s)
- L Cui; P T Thuong; Hyun Sun Lee; D T Ndinteh; J T Mbafor; Z T Fomum; W K Oh
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry, vol. 16, no. 24, pp. 10356-10362
- Publication Year
- 2008
- Abstract
- Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC50 values ranging from 13.9 ± 2.1 to 19.0 ± 1.8 μM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B.
- ISSN
- 0968-0896
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.bmc.2008.10.012
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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