Transcriptome analysis of the zebrafish mind bomb mutant

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Title
Transcriptome analysis of the zebrafish mind bomb mutant
Author(s)
J Hwang; H S Kim; J W Seok; J D Kim; S Koun; S Y Park; J Lee; H S Kim; H S Kim; K S Kim; Kyu Tae Chang; Z Y Ryoo; S M Wang; T L Huh; S Lee
Bibliographic Citation
Molecular Genetics and Genomics, vol. 281, no. 1, pp. 77-85
Publication Year
2009
Abstract
Mind bomb (Mib) facilitates Notch signaling pathway by promoting the endocytosis of Notch ligand. The zebrafish mibta52b mutant has a defect in its ubiquitin ligase activity which is necessary to inhibit the neurogenesis, resulting in a neuronal hyperplasia. Several genes regulated in the mibta52b mutant have been well established, however, there were relatively few reports about the transcriptome profile. To identify the genes differentially expressed in the mibta52b mutant, genome-wide analysis was performed using serial analysis of gene expression. Three hundred and thirty-five transcripts were identified whose expressions were significantly altered in the mibta52b mutant as compared with the wild-type. Interestingly, it was suggested that the mibta52b mutation may affect not only neurogenesis but also mesoderm development. These results provide new insights into Notch signaling pathway.
Keyword
genome-wide analysismind bombSAGEtranscriptome
ISSN
0026-8925
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s00438-008-0395-5
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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