돌단풍(Aceriphyllum rossii)에서 분리한 플라보노이드의 항암활성 = Anti-cancer activity of flavonoids from Aceriphyllum rossii

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Title
돌단풍(Aceriphyllum rossii)에서 분리한 플라보노이드의 항암활성 = Anti-cancer activity of flavonoids from Aceriphyllum rossii
Author(s)
E M Ahn; J T Han; Byoung-Mog Kwon; S H Kim; N I Baek
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 51, no. 4, pp. 309-315
Publication Year
2008
Abstract
The methanol extract from the aerial parts of Aceriphyllum rossii was fractionated into ethyl acetate, n-BuOH and H2O layers through solvent fractionation. Repeated silica gel column chromatography of EtOAc and n-BuOH layers afforded five flavonol glycosides. They were identified as astragalin (1), kaempferol 3-O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (2), rutin (3), kaempferol 3-O-α-L-rhamnopyranosyl (1→4)-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (4), and quercetin 3-O-α-L-rhamnopyranosyl (1→4)-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (5) on the basis of spectroscopic data. All of them showed an inhibition in farnesyl protein tranferase (FPTase) activity, and rutin (3) inhibited the growth of rat H-ras cell and the cell migration of human umbilical vein endothelial cells (HUVECs).
Keyword
aceriphyllum rossiianti-cancercell migrationflavonol glycosideFPTaseH-ras
ISSN
I000-0171
Publisher
Springer
DOI
http://dx.doi.org/10.3839/jksabc.2008.054
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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