Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses

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Title
Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses
Author(s)
Hwa-Jung Choi; C H Lim; J H Song; S H Baek; Dur Han Kwon
Bibliographic Citation
Phytomedicine, vol. 16, no. 1, pp. 35-39
Publication Year
2009
Abstract
RNA viruses are a major source of respiratory diseases worldwide. The lack of effective therapeutical treatment underlines the importance of research for new antiviral compounds. Raoulic acid is a principal ingredient of the plant Raoulia australis Hook. F. Antiviral assay using cytopathic effect (CPE) reduction method showed that raoulic acid possessed strong antiviral activity against human rhinovirus 2 (HRV2) with a 50% inhibition concentration (IC50) value of less than 0.1 μg/ml, human rhinovirus 3 (HRV3) with a IC50 value of 0.19 μg/ml, coxsackie B3 (CB3) virus with IC50 values of 0.33 μg/ml, coxsackie B4 (CB4) virus with IC50 values of 0.40 μg/ml, and enterovirus 71 (EV71) virus with IC50 values of less than 0.1 μg/ml. However, the compound did not possess antiviral activity against influenza A (Flu A/PR, Flu A/WS, H1N1) and B viruses at four concentrations ranging from 0.1 to 100 μg/ml.
Keyword
Raoulia australisRaoulic acidAntiviral activity
ISSN
0944-7113
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.phymed.2008.10.012
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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