Synthesis and cytotoxic activities of C-benzylated flavonoids

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Title
Synthesis and cytotoxic activities of C-benzylated flavonoids
Author(s)
Y J Choi; Hwan Mook Kim; H D Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 32, no. 1, pp. 59-63
Publication Year
2009
Abstract
Some C-benzylated flavonoids based on gericudranin A were synthesized and evaluated their cytotoxic activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules in 67 steps via sequential protection, aldol condensation, cyclization, regioselective C-benzylation, and deprotection. The cellular growth inhibition of the synthetic C-benzylated flavonoids was investigated against sixteen human cancer cell lines. Among these compounds, 5b showed the most potent cytotoxicities against several cell lines, especially as potent as adriamycin against SNB19 cell lines with an IC50 value of 0.7 μM.
Keyword
C-benzylated flavonoidcytotoxicitygericudranin ASARsynthesis
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-009-1118-0
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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