Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles

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Title
Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles
Author(s)
W S Cho; M Cho; Jin Young Jeong; M Choi; H Y Cho; B S Han; S H Kim; H O Kim; Yong Taik Lim; Bong Hyun Chung; J Jeong
Bibliographic Citation
Toxicology and Applied Pharmacology, vol. 236, no. 1, pp. 16-24
Publication Year
2009
Abstract
In general, gold nanoparticles are recognized as being as nontoxic. Still, there have been some reports on their toxicity, which has been shown to depend on the physical dimension, surface chemistry, and shape of the nanoparticles. In this study, we carry out an in vivo toxicity study using 13 nm-sized gold nanoparticles coated with PEG (MW 5000). In our findings the 13 nm sized PEG-coated gold nanoparticles were seen to induce acute inflammation and apoptosis in the liver. These nanoparticles were found to accumulate in the liver and spleen for up to 7 days after injection and to have long blood circulation times. In addition, transmission electron microscopy showed that numerous cytoplasmic vesicles and lysosomes of liver Kupffer cells and spleen macrophages contained the PEG-coated gold nanoparticles. These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications.
Keyword
accumulationgold nanoparticlesinflammationintravenous injectionpharmacokinetics
ISSN
0041-008X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.taap.2008.12.023
Type
Article
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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