Farnesyl protein transferase inhibitory components of Polygonum multiflorum

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Title
Farnesyl protein transferase inhibitory components of Polygonum multiflorum
Author(s)
Byoung-Mog Kwon; S H Kim; N I Baek; S I Lee; E J Kim; J H Yang; B S Chae; J H Lee; H W Park; J S Park; D K Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 32, no. 4, pp. 495-499
Publication Year
2009
Abstract
The methanolic extract of the roots of Polygonum multiflorum (Polygonaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone glycosides, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.
Keyword
anthraquinone glycosidesFPTasepolygonaceaepolygonum multiflorum
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-009-1403-y
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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