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- Title
- Farnesyl protein transferase inhibitory components of Polygonum multiflorum
- Author(s)
- Byoung-Mog Kwon; S H Kim; N I Baek; S I Lee; E J Kim; J H Yang; B S Chae; J H Lee; H W Park; J S Park; D K Kim
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 32, no. 4, pp. 495-499
- Publication Year
- 2009
- Abstract
- The methanolic extract of the roots of Polygonum multiflorum (Polygonaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone glycosides, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.
- Keyword
- anthraquinone glycosidesFPTasepolygonaceaepolygonum multiflorum
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- DOI
- http://dx.doi.org/10.1007/s12272-009-1403-y
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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