Inhibition of phenotypic and functional maturation of dendritic cells by manassantin A

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Title
Inhibition of phenotypic and functional maturation of dendritic cells by manassantin A
Author(s)
J Y Kim; Jong Soon Kang; Hwan Mook Kim; Young Kook Kim; H K Lee; S Song; J T Hong; Y Kim; S B Han
Bibliographic Citation
Journal of Pharmacological Sciences, vol. 109, no. 4, pp. 583-592
Publication Year
2009
Abstract
Manassantin A (MSA) inhibits nitric oxide production by macrophages through the inhibition of NF-κB activation, but the effect of MSA on dendritic cells has not been elucidated yet. Here we investigated the inhibitory effects of MSA on immune functions of dendritic cells (DCs). MSA inhibited lipopolysaccharide (LPS)-induced phenotypic maturation of DCs, which was proved by the decreased expression of CD40, CD80, CD86, MHC-I, and MHC-II. MSA also inhibited functional maturation of DCs, that is, decreased the gene expression of IL-12, IL-1β, TNF-α, and IFN-α/β; enhanced antigen capture capacity of DCs; and impaired induction of allogenic T cell activation. As a mechanism of action, MSA inhibited LPS-induced activation of NF-κB, ERK, p38, and JNK, which played pivotal roles in toll-like receptor 4-mediated DC maturation. Collectively, these results suggested that MSA might be used for the treatment of DC-related immune diseases.
Keyword
manassantin Adendritic cellmaturationmitogen-activated protein kinaseNF-κB
ISSN
1347-8613
Publisher
Japanese Pharmacological Soc
DOI
http://dx.doi.org/10.1254/jphs.08299FP
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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