Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi

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Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi
Yon Mi Lee; Jae Sun Moon; B S Yun; K D Park; G J Choi; J C Kim; S H Lee; Sung Uk Kim
Bibliographic Citation
Journal of Agricultural and Food Chemistry, vol. 57, no. 13, pp. 5750-5755
Publication Year
An antifungal compound was isolated from methanol extracts of stems and roots of Chloranthus henryi Hemsl. using ethyl acetate extraction and various chromatographic techniques. On the basis of spectroscopic analyses including mass and various NMR, the structure of the compound was identified as a dimeric sesquiterpene, CHE-23C. The compound showed potent antifungal activities (MICs = 1-32 μg/mL) in vitro against various phytopathogenic fungi such as Alternaria kikuchiana, Botrytis cinerea, Colletotrichum lagenarium, Magnaporthe grisea, Pythium ultimum, and Phytophthora infestans. In particular, it exhibited 91 and 100% disease-control activity in vivo against tomato late blight (P. infestans) and wheat leaf rust (Puccinia recondita) at concentrations of 33 and 100 μg/mL, respectively. The disease-control activity of this compound was stronger than that of the commercially available fungicide chlorothalonil, but weaker than that of dimethomorph. Therefore, the compound might serve as an interesting lead to develop effective antifungal agents.
chloranthus henryiCHE-23Cantifungal activityphytophthora infestanspuccinia recondita
Amer Chem Soc
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Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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