Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE2, and TNF-α production

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Title
Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE2, and TNF-α production
Author(s)
T M Hung; N H Dang; J C Kim; J S Choi; Hyeong Kyu Lee; B S Min
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 15, pp. 4389-4393
Publication Year
2009
Abstract
Three new phenolic glycosides, salviifosides A-C (1-3), and three known compounds salicin (4), kaempferol (5), and kaempferol 3-O-β-D-glucopyranoside (6) were isolated from the leaves of Alangium salviifolium (L.f.) Wangerin (Alangiaceae). The structures of the new metabolites were determined on the basic of spectroscopic analyses including two dimensional NMR. The anti-inflammatory activities of new compounds (1-3) were investigated on lipopolysaccharide (LPS)-induced murine macrophage cells line, RAW 264.7. Salviifoside B (2) potentially inhibits the productions of nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor-a (TNF-α).
Keyword
AlangiaceaePhenolic glycosidesAnti-inflammatoryAlangium salviifolium
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2009.05.070
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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