C5-Modified nucleosides exhibiting anticancer activity

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Title
C5-Modified nucleosides exhibiting anticancer activity
Author(s)
Y S Lee; S M Park; Hwan Mook Kim; Song Kyu Park; Kiho Lee; Chang Woo Lee; B H Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 16, pp. 4688-4691
Publication Year
2009
Abstract
We describe (i) a simple method for the synthesis of C5-modified nucleosides from 5-iodo-20-deoxyuridine and (ii) their activity against six types of human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN). We generated nitrile oxides in situ from oximes using a commercial bleaching agent; their cycloadditions with 5-ethynyl-20-deoxyuridine yielded isoxazole derivatives possessing activity against the cancer cell lines. We synthesized several azides from benzylic bromides and their click reactions with 5-ethynyl-20-deoxyuridine provided triazole derivatives.
Keyword
AnticancerNucleosideTriazoleIsoxazoleCycloaddition
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2009.06.072
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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