Open Access@KRIBBOchang Branch InstituteDivision of National Bio-InfrastructureLaboratory Animal Resource & Research Center1. Journal Articles
C5-Modified nucleosides exhibiting anticancer activity
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Y S Lee | - |
| dc.contributor.author | S M Park | - |
| dc.contributor.author | Hwan Mook Kim | - |
| dc.contributor.author | Song Kyu Park | - |
| dc.contributor.author | Kiho Lee | - |
| dc.contributor.author | Chang Woo Lee | - |
| dc.contributor.author | B H Kim | - |
| dc.date.accessioned | 2017-04-19T09:14:14Z | - |
| dc.date.available | 2017-04-19T09:14:14Z | - |
| dc.date.issued | 2009 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | 10.1016/j.bmcl.2009.06.072 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9061 | - |
| dc.description.abstract | We describe (i) a simple method for the synthesis of C5-modified nucleosides from 5-iodo-20-deoxyuridine and (ii) their activity against six types of human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN). We generated nitrile oxides in situ from oximes using a commercial bleaching agent; their cycloadditions with 5-ethynyl-20-deoxyuridine yielded isoxazole derivatives possessing activity against the cancer cell lines. We synthesized several azides from benzylic bromides and their click reactions with 5-ethynyl-20-deoxyuridine provided triazole derivatives. | - |
| dc.publisher | Elsevier | - |
| dc.title | C5-Modified nucleosides exhibiting anticancer activity | - |
| dc.title.alternative | C5-Modified nucleosides exhibiting anticancer activity | - |
| dc.type | Article | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
| dc.citation.number | 16 | - |
| dc.citation.endPage | 4691 | - |
| dc.citation.startPage | 4688 | - |
| dc.citation.volume | 19 | - |
| dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
| dc.contributor.affiliatedAuthor | Song Kyu Park | - |
| dc.contributor.affiliatedAuthor | Kiho Lee | - |
| dc.contributor.affiliatedAuthor | Chang Woo Lee | - |
| dc.contributor.alternativeName | 이윤석 | - |
| dc.contributor.alternativeName | 박선민 | - |
| dc.contributor.alternativeName | 김환묵 | - |
| dc.contributor.alternativeName | 박성규 | - |
| dc.contributor.alternativeName | 이기호 | - |
| dc.contributor.alternativeName | 이창우 | - |
| dc.contributor.alternativeName | 김병현 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 16, pp. 4688-4691 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2009.06.072 | - |
| dc.subject.keyword | Anticancer | - |
| dc.subject.keyword | Nucleoside | - |
| dc.subject.keyword | Triazole | - |
| dc.subject.keyword | Isoxazole | - |
| dc.subject.keyword | Cycloaddition | - |
| dc.subject.local | Anti-cancer | - |
| dc.subject.local | Anticancer | - |
| dc.subject.local | anti-cancer | - |
| dc.subject.local | anticancer | - |
| dc.subject.local | Anti-Cancer | - |
| dc.subject.local | Nucleoside | - |
| dc.subject.local | Triazole | - |
| dc.subject.local | triazole. | - |
| dc.subject.local | triazole | - |
| dc.subject.local | Isoxazole | - |
| dc.subject.local | isoxazole | - |
| dc.subject.local | Cycloaddition | - |
| dc.description.journalClass | Y | - |
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