Open Access@KRIBBOchang Branch InstituteDivision of National Bio-InfrastructureLaboratory Animal Resource & Research Center1. Journal Articles
C5-Modified nucleosides exhibiting anticancer activity
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- Title
- C5-Modified nucleosides exhibiting anticancer activity
- Author(s)
- Y S Lee; S M Park; Hwan Mook Kim; Song Kyu Park; Kiho Lee; Chang Woo Lee; B H Kim
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 16, pp. 4688-4691
- Publication Year
- 2009
- Abstract
- We describe (i) a simple method for the synthesis of C5-modified nucleosides from 5-iodo-20-deoxyuridine and (ii) their activity against six types of human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN). We generated nitrile oxides in situ from oximes using a commercial bleaching agent; their cycloadditions with 5-ethynyl-20-deoxyuridine yielded isoxazole derivatives possessing activity against the cancer cell lines. We synthesized several azides from benzylic bromides and their click reactions with 5-ethynyl-20-deoxyuridine provided triazole derivatives.
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.bmcl.2009.06.072
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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