CIIA induces the epithelial-mesenchymal transition and cell invasion

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Title
CIIA induces the epithelial-mesenchymal transition and cell invasion
Author(s)
S Y Han; H S Hwang; J S Chae; Yang suk jin; J H Yoon; Young Il Yeom; E J Choi
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 387, no. 3, pp. 548-552
Publication Year
2009
Abstract
Epithelial.mesenchymal transition (EMT) and the acquisition of invasive potential are key events in tumor progression. We now show that CIIA, originally identified as an anti-apoptotic protein, induces the EMT and promotes cell migration and invasion. Ectopic expression of CIIA induced down-regulation of E-cadherin and claudin-1 as well as up-regulation of N-cadherin in MDCK cells. It also disrupted the differentiated epithelial morphology of MDCK cells grown in three-dimensional Matrigel cultures as well as increased the migration and invasion of MDCK cells in vitro. Furthermore, depletion of endogenous CIIA by RNA interference inhibited the migration and invasion of HeLa cells, and this inhibition was abolished by RNA interference-mediated depletion of claudin-1. These results suggest that CIIA functions as an inducer of cell invasion, and this effect is mediated, at least in part, through down-regulation of claudin-1.
Keyword
CIIAEpithelial.mesenchymal transitionMigrationInvasionClaudin-1
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2009.07.050
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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