A comparison of gene expression profiles between primary human AML cells and therapy-related AML cells

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Title
A comparison of gene expression profiles between primary human AML cells and therapy-related AML cells
Author(s)
Y H Kim; H S Kim; J Hwang; J Lee; S Kim; S Y Park; Kyu Tae Chang; K S Kim; Z Y Ryoo; S Lee
Bibliographic Citation
Biomolecules & Therapeutics, vol. 16, no. 4, pp. 431-436
Publication Year
2008
Abstract
To identify genes whose expression correlated with biological features of therapy-related AML (t-AML), we analyzed the expression profiles of de novo AML t(9;11) and t-AML t(9;11) bone marrow samples using previously published SAGE data. Three-hundred twenty-nine transcripts that satisfied statistical (P<0.05) and magnitude-of-change (≥ 4-fold) criteria were identified as differentially expressed between de novo AML t(9;11) and t-AML t(9;11) cells. of these transcripts, 301 (91%) matched known genes or ESTs and were classified according to functional categories (http://david.abcc.ncifcrf.gov/). The majority of differentially expressed genes in t-AML t(9;11) were involved in the regulation of biological and metabolic processes. Especially prominent among these were genes related to immune and drug responses. These results establish a framework for developing new drugs for the treatment of t-AML.
Keyword
Gene expressionSAGETherapy-related AML
ISSN
1976-9148
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4062/biomolther.2008.16.4.431
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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