Pseudomonas aeruginosa eliminates natural killer cells via phagocytosis-induced apoptosis

Cited 20 time in scopus
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Title
Pseudomonas aeruginosa eliminates natural killer cells via phagocytosis-induced apoptosis
Author(s)
J W Chung; Z H Piao; Suk Ran Yoon; Mi-Sun Kim; M Jeong; Suk Hyung Lee; Jeong Ki MinJae Wha Kim; Y H Cho; J C Kim; J K Ahn; K E Kim; In Pyo Choi
Bibliographic Citation
PLoS Pathogens, vol. 5, no. 8, pp. 1000561-1000561
Publication Year
2009
Abstract
Pseudomonas aeruginosa (PA) is an opportunistic pathogen that causes the relapse of illness in immunocompromised patients, leading to prolonged hospitalization, increased medical expense, and death. In this report, we show that PA invades natural killer (NK) cells and induces phagocytosis-induced cell death (PICD) of lymphocytes. In vivo tumor metastasis was augmented by PA infection, with a significant reduction in NK cell number. Adoptive transfer of NK cells mitigated PA-induced metastasis. Internalization of PA into NK cells was observed by transmission electron microscopy. In addition, PA invaded NK cells via phosphoinositide 3-kinase (PI3K) activation, and the phagocytic event led to caspase 9-dependent apoptosis of NK cells. PA-mediated NK cell apoptosis was dependent on activation of mitogen-activated protein (MAP) kinase and the generation of reactive oxygen species (ROS). These data suggest that the phagocytosis of PA by NK cells is a critical event that affects the relapse of diseases in immunocompromised patients, such as those with cancer, and provides important insights into the interactions between PA and NK cells.
ISSN
1553-7366
Publisher
Public Library of Science
DOI
http://dx.doi.org/10.1371/journal.ppat.1000561
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Biomaterials Research > Cell Factory Research Center > 1. Journal Articles
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