Nanogap biosensors for electrical and label-free detection of biomolecular interactions

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Title
Nanogap biosensors for electrical and label-free detection of biomolecular interactions
Author(s)
Sang Gyu Kim; Hyeon Min Jo; H J Park; Do-Hyeong Gwon; Jeong Min Lee; Bong Hyun Chung
Bibliographic Citation
Nanotechnology, vol. 20, no. 45, pp. 455502-455508
Publication Year
2009
Abstract
We demonstrate nanogap biosensors for electrical and label-free detection of biomolecular interactions. Parallel fabrication of nanometer distance gaps has been achieved using a silicon anisotropic wet etching technique on a silicon-on-insulator (SOI) wafer with a finely controllable silicon device layer. Since silicon anisotropic wet etching resulted in a trapezoid-shaped structure whose end became narrower during the etching, the nanogap structure was simply fabricated on the device layer of a SOI wafer. The nanogap devices were individually addressable and a gap size of less than 60nm was obtained. We demonstrate that the nanogap biosensors can electrically detect biomolecular interactions such as biotin/streptavidin and antigen/antibody pairs. The nanogap devices show a current increase when the proteins are bound to the surface. The current increases proportionally depending upon the concentrations of the molecules in the range of 100 fgml-1-100 ngml-1 at 1V bias. It is expected that the nanogap developed here could be a highly sensitive biosensor platform for label-free detection of biomolecular interactions.
ISSN
0957-4484
Publisher
IOP Publishing Ltd
DOI
http://dx.doi.org/10.1088/0957-4484/20/45/455502
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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