Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production

Cited 13 time in scopus
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Title
Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production
Author(s)
K Y Kim; A Baek; Y S Park; M Y Park; J H Kim; J S Lim; M S Lee; Suk Ran YoonHee Gu Lee; Y Yoon; D Y Yoon; Y Yang
Bibliographic Citation
Oncology Reports, vol. 22, no. 6, pp. 1497-1504
Publication Year
2009
Abstract
We explored whether adipocyte culture medium affects the secreted chemokine profile of tumor cells, because adipocytes stimulate progression or metastasis of breast cancer cells, and chemokines secreted from tumor cells are involved in these processes. CCL20 expression was dramatically increased, and an NF-κB blocker completely inhibited adipocyte culture medium-induced CCL20 expression in MDA-MB-231 cells. We showed that adipocyte culture medium increased the production of TNF-α in MDA-MB-231 cells, which stimulated CCL20 expression in an autocrine fashion. Our data also showed that CCL20 increased the migration and invasiveness of MDA-MB-231 cells, but did not affect the proliferation of these cells.
Keyword
AdipocytesBreast cancerCCL20
ISSN
1021-335X
Publisher
Spandidos Publ Ltd
DOI
http://dx.doi.org/10.3892/or_00000593
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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