Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca

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Title
Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca
Author(s)
Young-Hee Kim; In Ja Ryoo; Soo-Jin Choo; G H Xu; Sangku Lee; S J Seok; K Bae; Ick Dong Yoo
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 19, no. 10, pp. 1139-1141
Publication Year
2009
Abstract
Clitocybin D, a novel human neutrophil elastase inhibitor, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. The compound was determined to be 4-(4,6-dihydroxy-3-methoxy-3Hisoindol-1-yl)-benzoic acid on the basis of 1D and 2D NMRs and MS spectroscopic analysis. Analysis of the human neutrophil elastase (HNE) inhibitory activity of the isolated compound revealed that it showed significant HNE inhibitory activity with an IC50 value of 17.8 μM.
Keyword
Clitocybe aurantiacaClitocybin DHuman neutrophil elastase
ISSN
1017-7825
Publisher
South Korea
DOI
http://dx.doi.org/10.4014/jmb.0903.03033
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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