In silico analysis of gene function and transcriptional regulators associated with endoplasmic recticulum (ER) stress = Endoplasmic recticulum stress와 관련된 유전자기능과 전사조절인자의 in silico 분석

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Title
In silico analysis of gene function and transcriptional regulators associated with endoplasmic recticulum (ER) stress = Endoplasmic recticulum stress와 관련된 유전자기능과 전사조절인자의 in silico 분석
Author(s)
T M Kim; J Yeo; Chan Sun Park; Moon Soo Rhee; M H Jung
Bibliographic Citation
Journal of Life Science, vol. 19, no. 8, pp. 1159-1163
Publication Year
2009
Abstract
It has been postulated that endoplasmic (ER) stress is involved in the development of several diseases. However, the detailed molecular mechanisms have not been fully understood. Therefore, we characterized a genetic network of genes induced by ER stress using cDNA microarray and gene set expression coherence analysis (GSECA), and identified gene function as well as several transcription regulators associated with ER stress. We analyzed time-dependent gene expression profiles in thapsigargin-treated Sk-Hep1 using an oligonucleotide expression chip, and then selected functional gene sets with significantly high expression coherence which was processed into functional clusters according to the expression similarities. The functions related to sugar binding, lysosome, ribosomal protein, ER lumen, and ER to golgi transport increased, whereas the functions with mRNA processing, DNA replication, DNA repair, cell cycle, electron transport chain and helicase activity decreased. Furthermore, functional clusters were investigated for the enrichment of regulatory motifs using GSECA, and several transcriptional regulators associated with regulation of ER-induced gene expression were found.
Keyword
Endoplasmic recticulum(ER) stressgene expression microarraygene set expression coherence analysis (GSECA)gene functiontranscriptiontranscription regulator
ISSN
I000-0128
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5352/JLS.2009.19.8.1159
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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