Inhibition on LDL-oxidation by phenolic compounds from the fruit body of Phellinus linteus

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Title
Inhibition on LDL-oxidation by phenolic compounds from the fruit body of Phellinus linteus
Author(s)
H N Lyu; D Y Lee; M K Lee; M H Cho; Tae Sook Jeong; I H Kim; C H Lee; N I Baek
Bibliographic Citation
Journal of Applied Biological Chemistry, vol. 52, no. 3, pp. 147-150
Publication Year
2009
Abstract
The fruit body of Phellinus linteus was extracted with 80% aqueous MeOH, and the concentrated extract was successively partitioned using EtOAc, n-BuOH and . From the EtOAc and n-BuOH fractions, three phenolic compounds were isolated through repeated silica gel and ODS column chromatography. The chemical structures of these compounds were determined as 2-(3',4'-dihydroxyphenyl)-1,3-benzodioxole-5-aldehyde (1), 4-(3,4-dihydroxyphenyl)-3-buten-2-one (2), and protocatechuic acid methyl ester (3) by spectroscopic data including NMR, MS and IR. Compounds exhibited low density lipoprotein (LDL) antioxidant activity with values of 1.7, 0.7, and , respectively.
Keyword
2-(3',4'-dihydroxyphenyl)-1,3-benzodioxole-6-alehyde4-(3,4-dihydroxyphenyl)-3-buten-2-oneL이-oxi-dationPhellinusprotocatechuic acid methyl esterphenolic compound
ISSN
1229-2737
Publisher
Springer
DOI
http://dx.doi.org/10.3839/jabc.2009.025
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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