Viral interferon regulatory factors

Cited 56 time in scopus
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Title
Viral interferon regulatory factors
Author(s)
H R Lee; Myung Hee Kim; J S Lee; C Liang; J U Jung
Bibliographic Citation
Journal of Interferon and Cytokine Research, vol. 29, no. 9, pp. 621-627
Publication Year
2009
Abstract
Upon viral infection, the major defensive strategy employed by the host immune system is the activation of the interferon (IFN)-mediated antiviral pathway, which is overseen by IFN regulatory factors (IRFs). In order to complete their life cycles, viruses must find a way to modulate the host IFN-mediated immune response. Kaposi's sarcoma-associated herpesvirus (KSHV), a human tumor-inducing herpesvirus, has developed a unique mechanism for antagonizing cellular IFN-mediated antiviral activity by incorporating viral homolog of the cellular IRFs, called vIRFs, into its genome. Here, we summarize the novel evasion mechanisms by which KSHV, through its vIRFs, circumvents IFN-mediated innate immune responses and deregulates the cell growth control mechanism.
ISSN
1079-9907
Publisher
Mary Ann Liebert, Inc
DOI
http://dx.doi.org/10.1089/jir.2009.0067
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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