Comparative study on inhibitory activity of zerumbone and zerumbone 2,3-epoxide on NF-κB activation and NO production

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Title
Comparative study on inhibitory activity of zerumbone and zerumbone 2,3-epoxide on NF-κB activation and NO production
Author(s)
P M Giang; P T Son; H Z Jin; J H Lee; Jung Joon Lee
Bibliographic Citation
Scientia Pharmaceutica, vol. 77, no. 3, pp. 589-595
Publication Year
2009
Abstract
In the present study the significant role of the α,β-unsaturated carbonyl structure in the anti-inflammatory activity of the natural humulane sesquiterpenoids zerumbone and zerumbone 2,3-epoxide was evidenced from a comparative study of the ability of zerumbone and zerumbone 2,3-epoxide to inhibit NF-κB activation and NO production in LPS (lipopolysaccharide)- stimulated RAW 264.7 cells. The IC50 of these compounds were 1.97 μM ± 0.18 and 30.11 μM ± 4.10 in the NF-κB activation assay and 3.58 μM ± 0.46 and 34.7 μM ± 3.72 in the nitric oxide production assay, respectively.
Keyword
NF-κBNO productionZerumboneZerumbone-2,3-epoxide
ISSN
0036-8709
Publisher
?sterreichischer Apothekerverlag
DOI
http://dx.doi.org/10.3797/scipharm.0907-16
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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