Genome evolution and adaptation in a long-term experiment with Escherichia coli

Cited 773 time in scopus
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Title
Genome evolution and adaptation in a long-term experiment with Escherichia coli
Author(s)
J E Barrick; Dong Su Yu; Sung Ho Yoon; Haeyoung Jeong; Tae Kwang Oh; D Schneider; R E Lenski; Jihyun Kim
Bibliographic Citation
Nature, vol. 461, no. 7268, pp. 1243-1247
Publication Year
2009
Abstract
The relationship between rates of genomic evolution and organismal adaptation remains uncertain, despite considerable interest. The feasibility of obtaining genome sequences from experimentally evolving populations offers the opportunity to investigate this relationship with new precision. Here we sequence genomes sampled through 40,000 generations from a laboratory population of Escherichia coli. Although adaptation decelerated sharply, genomic evolution was nearly constant for 20,000 generations. Such clock-like regularity is usually viewed as the signature of neutral evolution, but several lines of evidence indicate that almost all of these mutations were beneficial. This same population later evolved an elevated mutation rate and accumulated hundreds of additional mutations dominated by a neutral signature. Thus, the coupling between genomic and adaptive evolution is complex and can be counterintuitive even in a constant environment. In particular, beneficial substitutions were surprisingly uniform over time, whereas neutral substitutions were highly variable.
ISSN
0028-0836
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/nature08480
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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