Steroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity

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Title
Steroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity
Author(s)
H W Seo; T M Hung; M Na; H J Jung; J C Kim; J S Choi; Jung Hee Kim; Hyeong Kyu Lee; I Lee; K Bae; M Hattori; B S Min
Bibliographic Citation
Archives of Pharmacal Research, vol. 32, no. 11, pp. 1573-1579
Publication Year
2009
Abstract
To determine the anti-complement activity of natural triterpenes, chromatographic separation of the EtOAc-soluble fraction from the fruiting body of Ganoderma lucidum led to the isolation of three steroids and five triterpenoids. They were identified as ergosterol peroxide (1), ergosterol (2), genoderic acid Sz (3), stella sterol (4), ganoderic aic C1 (5), ganoderic acid A (6), methyl ganoderate A (7), and lucidenic acid A (8) based on spectroscopic evidence and physicochemical properties. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Compounds 2 and 3 showed potent anti-complement activity with IC 50 values of 52.0 and 44.6 μM, respectively. Compound 1 exhibited significant inhibitory activity with an IC50 value of 126.8 μM, whereas compounds 4-8 were inactive. Our findings suggested that in addition to the ketone group at C-3, the Δ7(8), Δ9(11)- lanostadiene type triterpene also plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.
Keyword
Anti-complementary activityGanoderic acid SzLanostadiene triterpenePolyporaceaeGanoderma lucidum
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-009-2109-x
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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