Heterologous microarray hybridization used for differential gene expression profiling in Benzo[a]pyrene-exposed marine medaka
Cited 0 time in
- Heterologous microarray hybridization used for differential gene expression profiling in Benzo[a]pyrene-exposed marine medaka
- S Woo; H Won; H Y Jeon; B Kim; T K Lee; Hong-Seog Park; S Yum
- Bibliographic Citation
- Molecular & Cellular Toxicology, vol. 5, no. 4, pp. 283-290
- Publication Year
- Differential gene expression profiling was performed in the hepatic tissue of marine medaka fish (Oryzias javanicus) after exposure to benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), by heterologous hybridization using a medaka cDNA microarray. Thirty-eight differentially expressed candidate genes, of which 23 were induced and 15 repressed (P？0.01), were identified and found to be associated with cell cycle, development, endocrine/reproduction, immune, metabolism, nucleic acid/protein binding, signal transduction, or non-categorized. The presumptive physiological changes induced by BaP exposure were identified after considering the biological function of each gene candidate. The results obtained in this study will allow future studies to assess the molecular mechanisms of BaP toxicity and the development of a systems biology approach to the stress biology of organic chemicals.
- Oryzias javanicusHeterologous hybridizationMicroarray benzo[a]pyrene (BaP)Differential gene expression profileMarine medaka
- Korea Soc-Assoc-Inst
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.